anti-RSK3, mAb (3A3)

CHF 315.00
In stock
YIF-LF-MA0279100 µlCHF 315.00
More Information
Product Details
Synonyms RSK-3; p90RSK2; RPS6KA2; pp90RSK3; p90-RSK 2; MAPKAPK1C; MAPKAPK-1c; EC=; S6K-α-2; MAPKAP Kinase 1c; Ribosomal S6 Kinase 3; MAPK-activated Protein Kinase 1c
Product Type Monoclonal Antibody
Clone 3A3
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His/ABD-RSK3 (aa 415-733) protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, estrogen receptor, NFκB/IκB α, cAMP-response element-binding protein (CREB). ERK activates the C-terminal kinase of RSK, leading to activation of the N-terminal kinase. Members of the RSK family are present in the cytoplasm as well as the nucleus. Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation. The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors. Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Product References

1) Roux, P. P. et al., (2003) Mol Cell Biol. 23: 4796–4804 (General)
2) Frodin, M. and Gammeltoft ,S., (1999) Mol Cell Endocrinol. 151:65-77 (General)
3) Fisher, T. L. and Blenis, J., (1996) Mol. Cell. Biol. 16:1212-1219 (General)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.