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anti-RIP2, mAb (AF28D3)
Product Details | |
---|---|
Synonyms | RIP-2; RIPK2; CARDIAK; EC=2.7.11.1; EC=2.7.10.2; Tyrosine-Protein Kinase RIPK2; Receptor-interacting Protein 2; RIP-like-interacting CLARP Kinase; CARD-containing IL-1 β ICE-Kinase |
Product Type | Monoclonal Antibody |
Properties | |
Clone | AF28D3 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Recombinant human His-RIP2 protein purified from E. coli. |
Application |
ELISA |
Crossreactivity |
Human Mouse Rat |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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The RIP (receptor-interacting protein) family of serine/Threonine kinases (RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors(NF-κB and AP-1) and death-inducing programs. RIP2(also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-κB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-κB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK. Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-κB.
1) Kobayashi K et al., (2002) Nature 416, 194-199 (General)
2) Hasegawa M, (2008) EMBO 27, 373–383 (General)
3) Meylan E and Tschopp J, (2005) TRENDS in Biochem Sciences 30:151-159 (General)