anti-RIP2, mAb (AF28D3)

CHF 315.00
In stock
YIF-LF-MA0288100 µlCHF 315.00
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Product Details
Synonyms RIP-2; RIPK2; CARDIAK; EC=; EC=; Tyrosine-Protein Kinase RIPK2; Receptor-interacting Protein 2; RIP-like-interacting CLARP Kinase; CARD-containing IL-1 β ICE-Kinase
Product Type Monoclonal Antibody
Clone AF28D3
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-RIP2 protein purified from E. coli.

Western Blot (1:2,000)
Immunoprecipitation (3 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The RIP (receptor-interacting protein) family of serine/Threonine kinases (RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors(NF-κB and AP-1) and death-inducing programs. RIP2(also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-κB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-κB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK. Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-κB.

Product References

1) Kobayashi K et al., (2002) Nature 416, 194-199 (General)
2) Hasegawa M, (2008) EMBO 27, 373–383 (General)
3) Meylan E and Tschopp J, (2005) TRENDS in Biochem Sciences 30:151-159 (General)

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