anti-IRS2, mAb (AF2F2)

CHF 322.00
In stock
YIF-LF-MA0290100 µlCHF 322.00
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Product Details
Synonyms IRS2; IRS-2; Insulin Receptor Substrate 2
Product Type Monoclonal Antibody
Properties
Clone AF2F2
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-IRS2 protein purified from E. coli.
Application

ELISA
Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism through insulin/insulin like growth factor (IGF) signaling. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. After phosphorylation by activated receptors, these intracellular signaling molecules recruit various downstream effector pathways including phosphatidylinositol 3-kinase, tyrosine protein phosphatase SHPTP-2, and several smaller adapter molecules such as the growth factor receptor-binding protein Grb-2. IRSs are also thought to be able to induce malignant transformation. May mediate the control of various cellular processes by insulin.

Product References

1) Dearth R.K. et al., (2007) Cell Cycle. 6:705-713. (General)
2) White M.F., (2002) Am J Physiol Endocrinol Metab. 283:E413-E422. (General)
3) Burks D.J. and White M.F., (2001) Diabetes 50:S140-S145. (General)
4) Giovannone B. et al., (2000) Diabetes Metab Res Rev. 16:434-441. (General)

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