anti-MEK6 (MAP Kinase Kinase 6), mAb (AF8B6)

CHF 322.00
In stock
YIF-LF-MA0292100 µlCHF 322.00
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Product Details
Synonyms MEK6; MEK 6; MAP2K6; SAPKK3; MAPKK 6; SAPKK-3; EC=2.7.12.2; SAPK Kinase 3; MAPK/ERK Kinase 6; MAP Kinase Kinase 6; Stress-activated Protein Kinase Kinase 3
Product Type Monoclonal Antibody
Properties
Clone AF8B6
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-MEK6 protein purified from E. coli.
Application

ELISA
Immunoprecipitation (2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Sequential activation of protein kinases within the MAPK (mitogen-activated protein kinases) cascades is a common mechanism of signal transduction in many cellular processes. The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, and survival. Mitogen-activated protein kinase kinases (MAPKK) phosphorylate MAPK. MEK (MAP kinase or ERK kinase) is the immediate upstream activator kinase of ERK. MEK6 encodes a 334-amino acid protein with 82% identity to MKK3. MEK6 is highly expressed in skeletal muscle like many other members of this family, but in contrast to MKK3 its expression in leukocytes is very low. The human MEKs (MEK1, MEK2, MEK3) show remarkably different activity toward ERKl and ERK2. MEK2 is the most active ERK activator. MEK3 is inactive toward ERKl or ERK2. MEK3, MEK4, and MEK6 phosphorylate and activate p38 MAP kinase. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. Transcription factors such as ATF2 and Elk-1 are targets of the p38 MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.

Product References

1) Shaul YD and Seger R, (2007) Biochim Biophys Acta 1773(8):1213-1226. (General)
2) Raingeaud J et al., (1996) Mol Cell Biol 16(3):1247-1255. (General)
3) Stein B et al., (1996) J Biol Chem 271(19):11427-11433. (General)
4) Zheng CF and Guan KL, (1993) J Biol Chem 268:11435-11439. (General)

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