anti-Cofilin, mAb (AF2C2)

CHF 315.00
In stock
YIF-LF-MA0296100 µlCHF 315.00
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Product Details
Synonyms CFL; p18; CFL1; Cofilin-1; 18 kDa Phosphoprotein; Cofilin; Non-muscle Isoform
Product Type Monoclonal Antibody
Clone AF2C2
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-cofilin protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2a Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cofilin belongs to a family of related proteins with similar biochemical activities called the actin depolymerizing factor (ADF)/cofilin family. ADF/cofilins play an important role in cytokinesis , endocytosis, and in the development of all embryonic tissues. Cofilin is a small ubiquitous protein (~19 kDa) that is able to bind both G-actin (monomeric) and F-actin(filamentous actin). Cofilin promotes the regeneration of actin filaments by severing pre-existing filaments. LIMK or TESK play a central role in the regulation of the actin cytoskeleton by phosphorylating cofilin on Ser3. Phosphorylation of cofilin at Ser3 inhibits its ability to bind to actin. Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Product References

1) Wang W, Eddy R, Condeelis J, (2007) Nat Rev Cancer 7(6):429-40. (General)
2) Condeelis, J, (2001) Trends Cell Biol 11, 288-293. (General)
3) Scott RW and Olson MF, (2007) J Mol Med 85(6):555-68. (General)

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