anti-cdk4, mAb (AF10A4)

CHF 322.00
In stock
YIF-LF-MA0297100 µlCHF 322.00
More Information
Product Details
Synonyms CDK4; PSK-J3; EC=2.7.11.22; Cyclin-dependent Kinase 4; Cell Division Protein Kinase 4
Product Type Monoclonal Antibody
Properties
Clone AF10A4
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human MBP-CDK4 (aa 1-303) protein purified from E. coli.
Application

ELISA
Western Blot (1:2,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Progression through G1 is regulated by a complex mechanism that can involve at least three Cdks (Cdk4, Cdk6 and Cdk2) and their regulators. Cyclins of the D-type family (D1, D2, and D3) bind and activate CDK4 and CDK6, while E-type cyclins (E1 and E2) primarily interact with CDK2. CDK4 and 6 are cyclin D1 binding partners, and activated cyclin D1/CDK4 and cyclin D1/CDK6 complex phosphorylate the retinoblastoma protein (Rb) to induce the expression of target genes essential for S phase entry, resulting in facilitation of the progression from G1 to S phase. Cdk4 and Cdk6 are inhibited by Cip/Kip or INK family of proteins. Probably involved in the control of the cell cycle.

Product References

1) Malumbres M and Barbacid M, (2005) Trends Biochem Sci 30(11) :630-41. (General)
2) Fumi TY and Toshiyuki S, (2008) Cell Signal 20(4):581-9. (General)
3) Lee YM and Sicinski P, (2006) Cell Cycle 5(18):2110-4. (General)

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