anti-MKP2, mAb (AFPK7)

CHF 322.00
In stock
YIF-LF-MA0302100 µlCHF 322.00
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Product Details
Synonyms MKP2; DUSP4; MKP-2; EC=3.1.3.16; EC=3.1.3.48; MAP Kinase Phosphatase 2; Dual Specificity Protein Phosphatase 4; Dual Specificity Protein Phosphatase hVH2; Mitogen-activated Protein Kinase Phosphatase 2
Product Type Monoclonal Antibody
Properties
Clone AFPK7
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

ELISA
Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter. Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Product References

1) Shen WH et al., (2006) Cancer Res 66(12):6033-9. (General)
2) Teng CH et al., (2007) J Biol Chem 282(39):28395-407. (General)
3) Keyse SM, (2008) Cancer Metastasis Rev 27(2):253-61. (General)

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