anti-Aurora B, mAb (AF7B11)

CHF 322.00
In stock
YIF-LF-MA0305100 µlCHF 322.00
More Information
Product Details
Synonyms AIK2; AURKB; AIM-1; ARK-2; STK-1; Aurora 1; EC=2.7.11.1; Aurora Kinase B; Aurora-related Kinase 2; Aurora/IPL1-related Kinase 2; Serine/Threonine-Protein Kinase 5; Serine/Threonine-Protein Kinase 12
Product Type Monoclonal Antibody
Properties
Clone AF7B11
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-Aurora B protein purified from E. coli.
Application

ELISA
Western Blot (1:2,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Aurora protein kinase family (consisting of Aurora-A, -B and -C) is an important group of enzymes that controls several aspects of cell division in mammalian cells. In humans, Aurora-A is localized to the centrosome in prophase, subsequently spreading to the mitotic spindles/centrosomes. Aurora-B is found at the kinetochore, mainly at the midzone, during anaphase. Aurora-C is localized to the centrosomes from anaphase to cytokinesis. Aurora B is the catalytic component of the chromosomal passenger complex, which is composed of three additional noncatalytic subunits that direct its activity: survivin, INCEP, and borealin. Aurora B appears to be required for several mitotic processes, including aberrant chromosome alignment/segregation and cytokinesis. Phosphorylation of Histone H3 (Ser10 and Ser28) by Aurora B contributes to chromosome number instability and mitotic chromosome condensation. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1.

Product References

1) Vader G and Lens SM, (2008) Biochim Biophys Acta 1786(1):60-72. (General)
2) Gautschi O, (2008) Clin Cancer Res 14(6):1639-48. (General)
3) Hauf S et al., (2003) J Cell Biol 161,281-94. (General)

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