anti-HePTP, mAb (AFPK32)

CHF 322.00
In stock
YIF-LF-MA0306100 µlCHF 322.00
More Information
Product Details
Synonyms HEPTP; PTPN7; EC=; Protein-Tyrosine Phosphatase LC-PTP; Hematopoietic Protein-Tyrosine Phosphatase; Tyrosine-Protein Phosphatase Non-Receptor Type 7
Product Type Monoclonal Antibody
Clone AFPK32
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application ELISA
Western Blot (1:5,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
Hematopoietic tyrosine phosphatase (HePTP, PTPN7) belongs to a subgroup of PTPases with two other members, STEP and PCPTP1. HePTP is a 38 kDa class I non-receptor protein tyrosine phosphatase (PTP) that is strongly expressed in T cells. The protein consists of a short, amino-terminal extension that contains a conserved 16-amino acid kinase interaction motif (KIM) and a carboxy-terminal protein tyrosine phosphatase domain. HePTP binds the MAPK family kinases, Erk1/2 and p38 via KIM. Erk phosphorylates HePTP (at Thr45 and Ser72) and HePTP dephosphorylates Erk (at Tyr185). HePTP is phosphorylated at Ser23 within the KIM by PKA in T cells. This phosphorylation results in dissociation of the HePTP/ERK2 complex and reduced ability of HePTP to dephosphorylate ERK. Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Product References
1) Mustelin T et al., (2005) J Mol Biol 354:150-63. (General)
2) Eswaran J et al., (2006) Biochem J 395:483–491. (General)
3) Nika K et al., (2004) Biochem J 378:335-342. (General)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.