anti-IA-2, mAb (AFT38)

CHF 315.00
In stock
YIF-LF-MA0310100 µlCHF 315.00
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Product Details
Synonyms ICA3; PTPRN; ICA 512; R-PTP-N; PTP IA-2; IsleT Cell Antigen 512; IsleT Cell Autoantigen 3; Receptor-type Tyrosine-Protein Phosphatase-like N
Product Type Monoclonal Antibody
Clone AFT38
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2β were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic β–cell proliferation by regulating cyclins D through STATs. Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.

Product References

1) Primo ME et al., (2008) J Biol Chem 283(8):4674-81. (General)
2) Mziaut H et al, (2008) Proc Natl Acad Sci 105(2):674-9. (General)
3) Zhang G et al., (2007) J Endocrinol 195(2):313-21. (General)

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