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anti-Casein Kinase 1 ε, mAb (AF26H1)
Product Details | |
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Synonyms | CKIe; CSNK1E; EC=2.7.11.1; CKI-ε; Casein Kinase I Isoform ε |
Product Type | Monoclonal Antibody |
Properties | |
Clone | AF26H1 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Recombinant human His-Casein Kinase Ie protein purified from E. coli. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N- and C-terminal domains. Mammals have seven family members: α, β, γ1, γ2, γ3, δ and ε. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I ε is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation
1) Klimowski LK et al., (2006) FEBS J 273(20):4594-602. (General)
2) Knippschild U et al., (2005) Cell Signal 17(6):675-89. (General)
3) Hino S et al, (2003) J Biol Chem 278(16):14066-73. (General)