anti-MKP4 (pk12), mAb (AF11B5)

CHF 315.00
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YIF-LF-MA0317100 µlCHF 315.00
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Product Details
Synonyms MKP4; MKP-4; DUSP9; EC=; EC=; MAP Kinase Phosphatase 4; Dual Specificity Protein Phosphatase 9; Mitogen-activated Protein Kinase Phosphatase 4
Product Type Monoclonal Antibody
Clone AF11B5
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-MKP4 protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP4 (DUSP9) is a dual specificity phosphatase, which acts as a negative regulator of insulin-stimulated pathways. MKP4 is expressed in kidney, placenta and adipose tissue. MKP4, a cytosolic MKP with specificity to not only Erk, but also, to a lesser extent, JNK and p38. MKP4 also reversed the effect of TNF-α to inhibit insulin Signaling. MKP4 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance. Inactivates MAP kinases. Has a specificity for the ERK family.

Product References

1) Keyse SM, (2008) Cancer Metastasis Rev 27(2):253-61. (General)
2) Emanuelli B et al., (2008) Proc Natl Acad Sci 105(9):3545-50. (General)
3) Christie GR et al., (2005) Mol Cell Biol 25(18):8323-33. (General)

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