anti-MKP4 (pk12), mAb (AF11B5)

CHF 322.00
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YIF-LF-MA0317100 µlCHF 322.00
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Product Details
Synonyms MKP4; MKP-4; DUSP9; EC=; EC=; MAP Kinase Phosphatase 4; Dual Specificity Protein Phosphatase 9; Mitogen-activated Protein Kinase Phosphatase 4
Product Type Monoclonal Antibody
Clone AF11B5
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-MKP4 protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP4 (DUSP9) is a dual specificity phosphatase, which acts as a negative regulator of insulin-stimulated pathways. MKP4 is expressed in kidney, placenta and adipose tissue. MKP4, a cytosolic MKP with specificity to not only Erk, but also, to a lesser extent, JNK and p38. MKP4 also reversed the effect of TNF-α to inhibit insulin Signaling. MKP4 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance. Inactivates MAP kinases. Has a specificity for the ERK family.
Product References
1) Keyse SM, (2008) Cancer Metastasis Rev 27(2):253-61. (General)
2) Emanuelli B et al., (2008) Proc Natl Acad Sci 105(9):3545-50. (General)
3) Christie GR et al., (2005) Mol Cell Biol 25(18):8323-33. (General)
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