anti-SOS1, mAb (AF3F11)

CHF 322.00
In stock
YIF-LF-MA0318100 µlCHF 322.00
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Product Details
Synonyms SOS1; SOS-1; Son of Sevenless Homolog 1
Product Type Monoclonal Antibody
Properties
Clone AF3F11
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His/ABD-SOS1 protein purified from E. coli.
Application

ELISA
Western Blot (1:1,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex. Promotes the exchange of Ras-bound GDP by GTP.

Product References

1) Bernards A and Settleman J, (2007) Growth Factors 25(5):355-61. (General)
2) McDonald CB et al., (2008) Arch Biochem Biophys 479(1):52-62. (General)
3) Corbalan-Garcia S et al., (1996) Mol Cell Biol 16(10):5674-82. (General)

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