anti-Ferritin Light Chain, mAb (AF7B7)

CHF 315.00
In stock
YIF-LF-MA0326100 µlCHF 315.00
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Product Details
Synonyms FTL; Ferritin L Subunit; Ferritin Light Chain
Product Type Monoclonal Antibody
Clone AF7B7
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-FL protein purified from E. coli.

Western Blot (1:5,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. It is a holoenzyme shell (~450 kDa) consisting of 24 subunits of two types, H (heavy) and L (light), and capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiologic status of the cell, the ratio of H to L subunits in ferritin can vary widely. It can be viewed not only as part of a group of iron regulatory proteins that include transferrin and the transferrin receptor, but also as a member of the protein family that orchestrates the cellular defense against stress and inflammation. Ferritin is found in the liver, spleen, kidney and heart. Only a small amount is found in the blood. The blood level of ferritin serves as an indicator of the amount of iron stored in the body. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.

Product References

1) Theil EC, (2003) J Nutr 133;1549-1553. (General)
2) Torti FM and Torti SV, (2002) Blood 99;3505-3516. (General)
3) Arosio P and Levi S, (2002) Free Radic Biol Med 33(4);457-463. (General)

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