anti-Ferritin Light Chain, mAb (AF7B7)

CHF 322.00
In stock
YIF-LF-MA0326100 µlCHF 322.00
More Information
Product Details
Synonyms FTL; Ferritin L Subunit; Ferritin Light Chain
Product Type Monoclonal Antibody
Properties
Clone AF7B7
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-FL protein purified from E. coli.
Application

Western Blot (1:5,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. It is a holoenzyme shell (~450 kDa) consisting of 24 subunits of two types, H (heavy) and L (light), and capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiologic status of the cell, the ratio of H to L subunits in ferritin can vary widely. It can be viewed not only as part of a group of iron regulatory proteins that include transferrin and the transferrin receptor, but also as a member of the protein family that orchestrates the cellular defense against stress and inflammation. Ferritin is found in the liver, spleen, kidney and heart. Only a small amount is found in the blood. The blood level of ferritin serves as an indicator of the amount of iron stored in the body. Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.

Product References

1) Theil EC, (2003) J Nutr 133;1549-1553. (General)
2) Torti FM and Torti SV, (2002) Blood 99;3505-3516. (General)
3) Arosio P and Levi S, (2002) Free Radic Biol Med 33(4);457-463. (General)

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