anti-Casein Kinase 1 δ, mAb (AF12G4)

CHF 322.00
In stock
YIF-LF-MA0337100 µlCHF 322.00
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Product Details
Synonyms CKId; HCKID; CSNK1D; CKI-δ; EC=2.7.11.1; EC=2.7.11.26; Tau-Protein Kinase CSNK1D; Casein Kinase I Isoform δ
Product Type Monoclonal Antibody
Properties
Clone AF12G4
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-CK1d protein purified from E. coli.
Application

ELISA
Western Blot (1:5,000)
Immunoprecipitation (2 μl)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N- and C-terminal domains. Mammals have seven family members: α, β, γ1, γ2, γ3, δ, and ε. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase 1 δ is ubiquitously expressed in all tissues, is p53 dependently induced in stress situations and plays an important role in various cellular processes. PKA phosphorylates CK1δ, predominantly at Ser370 in vitro and in vivo, and that site-specific phosphorylation of CK1δ by PKA plays an important role in modulating CK1δ-dependent processes. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.

Product References

1) Knippschild U et al., (2005) Cell Signal 17(6):675-89. (General)
2) Stoter M et al, (2005) Oncogene 24(54):7964-75. (General)
3) Giamas G et al, (2007) Biochem J 406(3):389-98. (General)

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