anti-PEZ, mAb (T40-AF7C8)

CHF 315.00
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YIF-LF-MA0338100 µlCHF 315.00
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Product Details
Synonyms PEZ; PTPN14; EC=; Protein-Tyrosine Phosphatase Pez; Tyrosine-Protein Phosphatase Non-Receptor Type 14
Product Type Monoclonal Antibody
Clone T40-AF7C8
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:500)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Protein-tyrosine phosphatase 14 (PTPN14/PTPD2/PEZ) is a 130kDa multidomain cytosolic protein, and belongs to the NT6 subtype of PTPs. It is characterized by an N-terminal FERM domain (Band 4.1, ezrin, radixin, moesin homology) and a C-terminal PTP domain. Pez(Phosphatase with ezrin domain) may play a role in regulating endothelial cell proliferation during vascular injury and angiogenesis. B-Catenin, a central component of adherens junctions, has been identified as a PTPN14 substrate. TGF, which inhibits cell proliferation but not migration, also inhibits translocation of PTPN14 from the cytosol to the nucleus.

Product References

1) Wadham C et al, (2003) Mol Biol Cell 14(6):2520-9. (General)
2) Smith AL et al., (1995) Biochem Biophys Res Commun 209(3):959-65. (General)
3) Barr AJ et al, (2006) Proteins 63(4):1132-6. (General)

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