anti-PEZ, mAb (T40-AF7C8)
| Product Details | |
|---|---|
| Synonyms | PEZ; PTPN14; EC=3.1.3.48; Protein-Tyrosine Phosphatase Pez; Tyrosine-Protein Phosphatase Non-Receptor Type 14 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | T40-AF7C8 |
| Isotype | Mouse IgG1 κ |
| Immunogen/Antigen | Recombinant human protein purified from E. coli. |
| Application |
Western Blot (1:500) |
| Crossreactivity | Human |
| Purity Detail | Ammonium sulfate precipitation. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Protein-tyrosine phosphatase 14 (PTPN14/PTPD2/PEZ) is a 130kDa multidomain cytosolic protein, and belongs to the NT6 subtype of PTPs. It is characterized by an N-terminal FERM domain (Band 4.1, ezrin, radixin, moesin homology) and a C-terminal PTP domain. Pez(Phosphatase with ezrin domain) may play a role in regulating endothelial cell proliferation during vascular injury and angiogenesis. B-Catenin, a central component of adherens junctions, has been identified as a PTPN14 substrate. TGF, which inhibits cell proliferation but not migration, also inhibits translocation of PTPN14 from the cytosol to the nucleus.
1) Wadham C et al, (2003) Mol Biol Cell 14(6):2520-9. (General)
2) Smith AL et al., (1995) Biochem Biophys Res Commun 209(3):959-65. (General)
3) Barr AJ et al, (2006) Proteins 63(4):1132-6. (General)
