anti-Radixin, mAb (AF1H1)

CHF 315.00
In stock
YIF-LF-MA0339100 µlCHF 315.00
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Product Details
Synonyms RDX; Radixin
Product Type Monoclonal Antibody
Clone AF1H1
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-Radixin (aa 1-310) protein purified from E. coli.

Western Blot (1:10,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Ezrin, radixin and moesin (ERM) proteins are widely distributed proteins located in the cellular cortex, in microvilli and adherens junctions. They are mediate linkage of actin cytoskeleton to plasma membrane in many cells. ERM proteins contain an N-terminal FERM (4.1/ezrin/radixin/moesin) domain that binds to phosphatidylinositol-(4,5)phosphate and cellular membrane proteins. The ERM, particularly ezrin, is important for reconstructing cell-surface architecture during T cell activation. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation. ERM activity is regulated in part by phosphorylation at a C-terminal threonine (ezrin-Thr567, radixin-Thr564, moesin-Thr558). Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

Product References

1) Niggli V and Rossy J, (2008) Int J Biochem Cell Biol 40(3):344-9. (General)
2) Belkina NV et al., (2009) Proc Natl Acad Sci U S A 06(12):4707-12. (General)

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