anti-LDHA, mAb (AF14A11)

CHF 322.00
In stock
YIF-LF-MA0341100 µlCHF 322.00
More Information
Product Details
Synonyms LDHA; PIG19; LDH-A; LDH-M; EC=1.1.1.27; LDH Muscle Subunit; L-Lactate Dehydrogenase A Chain; Renal Carcinoma Antigen NY-REN-59; Cell Proliferation-inducing Gene 19 Protein
Product Type Monoclonal Antibody
Properties
Clone AF14A11
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-LDHA protein purified from E. coli.
Application

ELISA
Western Blot (1:2,000~1:10,000)
Immunoprecipitation (0.5 μl)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84–89% sequence similarities and 69–75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1α (HIF1α). LDHB is also known to be upregulated in many cancers.

Product References

1) Mdluli K et al., (2005) Biochim Biophys Acta 1753(2):209-16. (General)
2) Xie H et al, (2009) Mol Cancer Ther 8(3):626-35. (General)
3) Giatromanolaki A et al, (2008) Leuk Lymphoma 49(11) :2181-6. (General)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.