anti-TCPTP, mAb (T25-AF3B7)

CHF 322.00
In stock
YIF-LF-MA0344100 µlCHF 322.00
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Product Details
Synonyms PTPT; TCPTP; PTPN2; EC=; T-Cell Protein-Tyrosine Phosphatase; Tyrosine-Protein Phosphatase Non-Receptor Type 2
Product Type Monoclonal Antibody
Clone T25-AF3B7
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
T cell protein tyrosine phosphatase (TCPTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. TCPTP is ubiquitously expressed with particularly high expression in hematopoietic tissues and exists as two forms: an endoplasmic reticulum-targeted 48-kDa form (TC48) and a nuclear 45-kDa form (TC45). Although targeted to the nucleus, TC45 can exit in response to specific stimuli to dephosphorylate cytoplasmic substrates. TC-PTP is a negative regulator of the Jak/Stat cytokine signaling pathway. TCPTP is the PTP most closely related to PTP1B, with 72% sequence identity and 86% similarity in the catalytic domain.
Product References
1) Galic S et al., (2003) Mol Cell Biol 23(6):2096-108. (General)
2) Bourdeau A et al., (2007) Blood 109(10):4220-8. (General)
3) Doody KM et al., (2009) Immunol Rev 228(1):325-41. (General)
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