anti-PP1G, mAb (AF11F10)

CHF 322.00
In stock
YIF-LF-MA0348100 µlCHF 322.00
More Information
Product Details
Synonyms PP-1G; PPP1CC; EC=3.1.3.16; Protein Phosphatase 1C Catalytic Subunit; Serine/Threonine-Protein Phosphatase PP1-γ Catalytic Subunit
Product Type Monoclonal Antibody
Properties
Clone AF11F10
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-PP1G protein purified from E. coli.
Application

ELISA
Western Blot (1:5,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Protein phosphatase-1 (PP1) is one of the major Ser/Thr protein phosphatases and is ubiquitous in eukaryotic cells. PP1 is localized to its site of action by interacting with targeting or regulatory proteins, a majority of which contains a primary docking site referred to as the RVXF/W motif. The catalytic subunit of PP1 exists as three isoforms, PP1a, PP1b, and PP1r. The PP1 catalytic subunits are small proteins of 37kDa, which are highly conserved, with their main differences falling in the C-term. The PP1 catalytic subunit exists in the cell in complex with a large number of targeting/regulatory subunits, thereby generating different enzyme forms that allow it to perform a diverse number of cellular functions. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.

Product References

1) Moorhead GB et al., (2008) BMC Biochem 9:28. (General)
2) Gao Y, (2008) Biochemistry 28;47(43):11367-76. (General)

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