anti-Coilin, mAb (1H10)

CHF 322.00
In stock
YIF-LF-MA0358100 µlCHF 322.00
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Product Details
Synonyms p80; COIL; CLN80; Coilin
Product Type Monoclonal Antibody
Properties
Clone 1H10
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-Coilin protein purified from E. coli.
Application

Western Blot (1:2,000)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Coilin is a component of the nuclear Cajar (coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576-amino acid protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Product References

1) Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461–2473. (General)
2) Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841–852. (General)

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