anti-Coilin, mAb (1H10)

CHF 315.00
In stock
YIF-LF-MA0358100 µlCHF 315.00
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Product Details
Synonyms p80; COIL; CLN80; Coilin
Product Type Monoclonal Antibody
Clone 1H10
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-Coilin protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Coilin is a component of the nuclear Cajar (coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576-amino acid protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Product References

1) Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461–2473. (General)
2) Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841–852. (General)

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