anti-Coilin, mAb (3C11)
| Product Details | |
|---|---|
| Synonyms | p80; COIL; CLN80; Coilin |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 3C11 |
| Isotype | Mouse IgG1 κ |
| Immunogen/Antigen | Recombinant human His-Coilin protein purified from E. coli. |
| Application |
Immunoprecipitation (2 μg) |
| Crossreactivity | Human |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
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Coilin is a component of the nuclear Cajar (coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576-amino acid protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.
1) Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461–2473. (General)
2) Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841–852. (General)
