anti-Coilin, mAb (3C11)

Specifications / Handling

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Product Details
Synonyms	p80; COIL; CLN80; Coilin
Product Type	Monoclonal Antibody
Properties
Clone	3C11
Isotype	Mouse IgG1 κ
Immunogen/Antigen	Recombinant human His-Coilin protein purified from E. coli.
Application	Immunoprecipitation (2 μg)
Crossreactivity	Human
Formulation	Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by AbFrontier
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Description

Coilin is a component of the nuclear Cajar (coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576-amino acid protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Product References

1) Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461–2473. (General)
2) Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841–852. (General)

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