anti-Non Neuronal Enolase (NNE), mAb (9F7)

CHF 322.00
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YIF-LF-MA0362100 µlCHF 322.00
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Product Details
Synonyms NNE; ENO1; MPB-1; MBP-1; ENO1L1; Enolase 1; EC=4.2.1.11; α-Enolase; Non-Neural Enolase; Phosphopyruvate Hydratase; Plasminogen-binding Protein; C-Myc Promoter-binding Protein
Product Type Monoclonal Antibody
Properties
Clone 9F7
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-NNE protein purified from E. coli.
Application

Western Blot (1:10,000)
Immunoprecipitation (2 μg)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits, α, β and γ. Non Neuronal Enolase (ENO1) is an isoform of mammalian enolase and is composed of 2 α subunits. The gene for ENO1 also encodes a shorter monomeric structural lens protein, tau-crystallin. Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Used as a diagnostic marker for many tumors and, in the heterodimeric form, α/γ, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against α-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.

Product References

1) Ray R., Miller D.M. (1991) Mol. Cell. Biol. 11:2154-2161. (General)
2) Sugahara T. Et al. (1992) Cytotechnology 10:137-146. (General)
3) Ghosh A.K. Et al. (1999) Mol. Cell. Biol. 19:2880-2886. (General)
4) Feo S. Et al. (2000) FEBS Lett. 473:47-52. (General)
5) Lopez-Alemany R. Et al (2004) Am.J. Hematol. 72:234-242. (General)
6) Arza B. Et al. (1997) Thromb. Haemost. 78:1097-1103. (General)

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