anti-CRALBP, mAb (10A10)

CHF 315.00
In stock
YIF-LF-MA0366100 µlCHF 315.00
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Product Details
Synonyms RLBP1; CRALBP; Retinaldehyde-binding Protein 1; Cellular Retinaldehyde-binding Protein
Product Type Monoclonal Antibody
Clone 10A10
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-CRALBP protein purified from E. coli.

Western Blot (1:10,000)
Immunoprecipitation (2 μg)

Crossreactivity Mouse
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cellular retinaldehyde-binding protein (CRALBP) is a cytoplasmic protein, abundantly expressed in the retinal pigment epithelium (RPE) and Müller glia of the retina and in the pineal gland. Structurally, human CRALBP is a ∼36-kDa monomeric protein, proposed to adopt an “open” or “closed” conformation, depending on whether it is carrying an endogenous ligand. CRALBP interacts structurally and functionally with 11-cis-retinol dehydrogenase (RDH5), an enzyme of the visual cycle in RPE. CRALBP is a member of the CRAL_TRIO family of proteins that share a lipid-binding domain derived from the yeast Sec14 protein. Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. CRALBP knockout mice have a delayed response in rhodopsin regeneration, 11-cis-retinal production and dark adaptation after illumination. Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

Product References

1) Saari JC. Et al. (1978) J. Biol. Chem. 253(18)6432–6436. (General)
2) Futterman S, Saari JC. (1977) Invest. Ophthalmol. Vis. Sci. 16(8)768–771. (General)
3) Bunt-Milam AH, Saari JC. (1983) J. Cell Biol. 97(3)703–712. (General)
4) Wu Z. Et al. (2004) J. Biol. Chem. 279(26)27357–27364. (General)
5) Golovleva I. Et al. (2003) J. Biol. Chem. 278(14)12397–12402. (General)
6) Panagabko C. Et al. (2003) Biochemistry 42(21) 6467–6474. (General)

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