Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
anti-Peroxiredoxin 2, mAb (12B1)
Product Details | |
---|---|
Synonyms | TSA; PRP; NKEFB; PRDX2; NKEF-B; EC=1.11.1.15; Peroxiredoxin-2; Thioredoxin Peroxidase 1; Thiol-specific Antioxidant Protein; Natural Killer Cell-enhancing Factor B |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 12B1 |
Isotype | Mouse IgG2b κ |
Immunogen/Antigen | Recombinant human protein purified from E. |
Application |
Western Blot (1:500~1,000) |
Crossreactivity |
Human Mouse Rat |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
![]() |
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-α by regulating the intracellular concentrations of H2O2.
1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)
2) Rhee Sue Goo et al. (2001) IUBMB Life. 52:35-41. (General)
3) Min Hee Choi et al. (2005) Nature Letters 435(19) : 347-353. (General)