anti-R-PTP eta, mAb (T23-5E6)

CHF 322.00
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YIF-LF-MA0374100 µlCHF 322.00
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Product Details
Synonyms DEP1; PTPRJ; CD148; DEP-1; R-PTP-J; HPTP eta; R-PTP-eta; EC=3.1.3.48; Density-enhanced Phosphatase 1; Protein-Tyrosine Phosphatase eta; Protein-Tyrosine Phosphatase Receptor type J
Product Type Monoclonal Antibody
Properties
Clone T23-5E6
Isotype Mouse IgG2b
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Receptor-type tyrosine-protein phosphatase eta (also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA) is an enzyme that in humans is encoded by the PTPRJ gene [1-3]. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C γ 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF β receptor, and may be involved in UV-induced signal transduction [3]. PTPRJ has been shown to interact with CTNND1 [4]. Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Product References

1) Ostman A, et al. (1994), "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density". Proc Natl Acad Sci U S A 91 (21): 9680–4. (General)
2) Honda H, et al. (1995), "Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta". Blood 84 (12): 4186–94. (General)
3) "Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J“ (General)
4) Holsinger, LJ, et al. (2002), "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene (England) 21 (46): 7067–76. (General)

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