Glutaredoxin 1 (human) (rec.)

CHF 215.00
In stock
YIF-LF-P00030.1 mgCHF 215.00
More Information
Product Details
Synonyms GRX; GLRX; TTase-1; Glutaredoxin-1; Thioltransferase-1
Product Type Protein
Source/Host E. coli
Crossreactivity Human
Biological Activity

130U/mg (One unit will cause the oxidation of 1μmole of NADPH per min)

Purity ≥95% (SDS-PAGE)
Concentration 1 mg/ml
Formulation Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH (1). First discovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues (2). The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kD dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress (3).

Product References

1) Holmgren, A. (1990) p. 146-154, CRC Press Inc., Boca Raton, FL. (General)
2) Holmgren, A. (1989) J. Biol. Chem. 264, 13963-13966. (General)
3) Jung, C. H. and Thomas, J. A. (1996) Arch. Biochem. Biophys. 335, 61-72. (General)
4) Alexios, V. et al. (1997) J. Biol. Chem. 272, 11236-11243. (General)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.