Peroxiredoxin 6 (human) (rec.)

CHF 366.00
In stock
YIF-LF-P00040.5 mgCHF 366.00
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Product Details
Synonyms AOP2; PRDX6; NSGPx; aiPLA2; 1-Cys PRX; EC=3.1.1.-; EC=1.11.1.9; EC=1.11.1.15; 24 kDa Protein; Peroxiredoxin-6; 1-Cys Peroxiredoxin; Liver 2D Page Spot 40; Antioxidant Protein 2; Red Blood Cells Page Spot 12; Non-Selenium Glutathione Peroxidase
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1).

Product References

1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)

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