Methionine Sulfoxide Reductase B SelCys95Cys (human) (rec.)

CHF 334.00
In stock
YIF-LF-P00120.5 mgCHF 334.00
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Product Details
Synonyms SelX; SEPX1; MsrB1; MSRB1; HSPC270; EC=1.8.4.-; Selenoprotein X; Methionine-R-Sulfoxide Reductase B1
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM HEPES, pH 7.4.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Methionine sulfoxide reductase B (MsrB), also known as SelX, is a selenoprotein. The oxidation of methionine at the sulfur atom leads to alternative epimers: R form of Met(O) and S form of Met(O). MsrB can reduce R form of both free and protein-incorporated methionine sulfoxide to methionine. It has a crucial role in protecting cells against oxidative damages. MsrA reduces only the S epimer of Met(O), and MsrB reduces the R epimer of Met(O) in proteins. Although the catalytic mechanisms of MsrA and MsrB are similar, two Msrs have no sequence identity and no structural similarity.

Product References

1) Zheung, D. et al. (2003) J. Biomol. NMR, 27, 183-184. (General)
2) Weissbach, H. (2002) Arch.Biochem.Biophys. 397(2), 172-178. (General)
3) Kryukov, G. (2002) Proc.Natl.Acad.Sci.U.S.A. 99(7), 4245-4250. (General)

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