Glutathione Peroxidase 4 SelCys73Cys (human) (rec.)

CHF 334.00
In stock
YIF-LF-P00150.5 mgCHF 334.00
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Product Details
Synonyms GPX4; GPx-4; PHGPx; GSHPx-4; EC=1.11.1.12; Glutathione Peroxidase 4; Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM HEPES, pH 7.4.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/ mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract (1). Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation (2). Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine (3). All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).

Product References

1) Takebe, G.. et al. (2002) J. Biol. Chem. 277, 41254-41258. (General)
2) Avissar, N. et al. (1994) Am. J. Physiol. 267, E68-76. (General)
3) Bao, Y. et al. (1997) FEBS Lett. 410, 210-212. (General)
4) Chambers, I. et al. (1986) EMBO J. 5, 1221-1227. (General)
5) Perry, A. et al. (1992) Biochem. J. 285, 863-870. (General)

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