Methionine Sulfoxide Reductase A (human) (rec.)

CHF 334.00
In stock
YIF-LF-P00220.1 mgCHF 334.00
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Product Details
Synonyms PMSR; MSRA; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Concentration 1 mg/ml
Formulation Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Methione sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system, MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin (1), HIV protease (2) and a1-proteinase-inhibitor (3). Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals (4).

Product References

1) Sun, H. et al. (1999) Biochemistry. 38, 105-112. (General)
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311. (General)
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 7483-7486. (General)
4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666. (General)
5) Moskovitz, J. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2095-2099. (General)

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