Methionine Sulfoxide Reductase A (human) (rec.)

CHF 327.00

In stock

YIF-LF-P00220.1 mgCHF 327.00

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Product Details
Synonyms	PMSR; MSRA; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase
Product Type	Protein
Properties
Source/Host	E. coli
Crossreactivity	Human
Biological Activity	6.3U/mg
Purity	≥95% (SDS-PAGE)
Concentration	1 mg/ml
Formulation	Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by AbFrontier
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Description

Methione sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system, MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin (1), HIV protease (2) and a1-proteinase-inhibitor (3). Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals (4).

Product References

1) Sun, H. et al. (1999) Biochemistry. 38, 105-112. (General)
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311. (General)
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 7483-7486. (General)
4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666. (General)
5) Moskovitz, J. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2095-2099. (General)

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