Glutathione Reductase (human) (rec.)

CHF 366.00
In stock
YIF-LF-P00240.5 mgCHF 366.00
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Product Details
Synonyms GR; GSR; GLUR; GRase; EC=1.8.1.7; Glutathione Reductase, Mitochondrial
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Biological Activity

19.4U/mg (One unit will reduce 1 μmole of oxidized glutathione per min at pH7.5 at 25°C)

Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM HEPES, pH 7.5.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG) (1): GSSG + NADPH + H+ ⇔ 2GSH + NADP+ In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis (2).

Product References

1) Carlberg, I. and Mannervik, B. (1985) J. Biol. Chem. 261: 1629-1635. (General)
2) Picaud, T. and Desbois, A. (2002) J. Biol. Chem. 277: 31715-31721. (General)

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