14-3-3β (human) (rec.)

CHF 366.00
In stock
YIF-LF-P00400.5 mgCHF 366.00
More Information
Product Details
Synonyms YWHAB
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM Tris, 10mM NaCl, pH8.0.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (β, γ, ε, η, ζ, σ and τ/θ) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.

Product References

1) Tzivion, G. et al. (2001) Oncogene, 20, 6331-6338. (General)
2) Tzivion, G. and Avruch, J. (2002) J.Biol.Chem. 277, 3061-3064. (General)
3) Berg, D. et al. (2003) Nat. Rev. Neurosci. 4(9), 752-762. (General)

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