14-3-3β (human) (rec.)
Activity has not been tested.
|Formulation||Lyophilized from 20mM Tris, 10mM NaCl, pH8.0.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by AbFrontier|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Use/Stability||After reconstitution, store at -80°C.|
|Product Specification Sheet|
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (β, γ, ε, η, ζ, σ and τ/θ) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
1) Tzivion, G. et al. (2001) Oncogene, 20, 6331-6338. (General)
2) Tzivion, G. and Avruch, J. (2002) J.Biol.Chem. 277, 3061-3064. (General)
3) Berg, D. et al. (2003) Nat. Rev. Neurosci. 4(9), 752-762. (General)