Ubiquitin+1 (human) (rec.)
Activity has not been tested.
|Formulation||Liquid in 20mM HEPES, pH7.0, 10% Glycerol.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by AbFrontier|
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-80°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Product Specification Sheet|
Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-β and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.
1) Van Leeuwen, F.W. et al. (1998) Science, 279, 242-247. (General)
2) Van Leeuwen, F.W. et al. (1998) Trends Neurosci. 21(8), 331-335. (General)