Ubiquitin+1 (human) (rec.)

CHF 215.00
In stock
YIF-LF-P00420.5 mgCHF 215.00
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Product Details
Synonyms UBB; Frameshift
Product Type Protein
Source/Host E. coli
Crossreactivity Human
Biological Activity

Activity has not been tested.

Purity ≥95% (SDS-PAGE)
Concentration 1 mg/ml
Formulation Liquid in 20mM HEPES, pH7.0, 10% Glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-β and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.

Product References

1) Van Leeuwen, F.W. et al. (1998) Science, 279, 242-247. (General)
2) Van Leeuwen, F.W. et al. (1998) Trends Neurosci. 21(8), 331-335. (General)

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