Diazepam Binding Inhibitor (human) (rec.)

CHF 219.00
In stock
YIF-LF-P00460.5 mgCHF 219.00
 
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Product Details
Synonyms EP; DBI; ACBP; Endozepine; Acyl-CoA-binding Protein; Diazepam-binding Inhibitor
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM HEPES, pH 7.4.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Diazepam Binding Inhibitor (DBI) is a highly conserved 10 kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer’s disease.
Product References
1) Shoyab, M. et al (1986) J. Biol. Chem. 261: 11968-11973. (General)
2) Gray, P.W. et al (1986) Proc. Nat. Acad. Sci. 83:7547-7551. (General)
3) Ohkuma, S. et al (2001) Life Science 68: 1215-1222. (General)
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