Catecholamine-sulfating Phenol Sulfotransferase (human) (rec.)
|Synonyms||STM; HAST3; M-PST; TL-PST; SULT1A3; EC=220.127.116.11; ST1A3/ST1A4; Sulfotransferase 1A3/1A4; Aryl Sulfotransferase 1A3/1A4; Placental Estrogen Sulfotransferase; Thermolabile Phenol Sulfotransferase; Sulfotransferase; Monoamine-preferring|
Activity has not been tested.
|Formulation||Liquid in 20mM HEPES, pH7.0, 10% Glycerol.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by AbFrontier|
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-80°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Product Specification Sheet|
The human Catecholamine-Sulfating Phenol Sulfotransferase (CSPS) is the only sulfotransferase that catalyses the sulfation of catecholamins, in particular the neurotransmitter dopamine, with high activity. CSPS is required for stimulation by Mn2+ of the sulfating activity and expressed in the human intestine, brain, platelet and other tissues. In the brain it may play a role in regulating the levels of dopamine. It also serves as a detoxifying function in the intestine, where it may detoxify potentially lethal dietary monoamines.
1) Pai, T.G. et al. (2003) J. Biol. Chem. 278, 1525-1532. (General)
2) Pai, T.G. et al. (2002) J. Biol. Chem. 277,43813-43820. (General)
3) Coughtrie, M.W.H. (2002) Pharmacogenomics J. 2, 297-308. (General)