β-Amyloid 40 (human) (rec.)

CHF 334.00
In stock
YIF-LF-P00500.5 mgCHF 334.00
More Information
Product Details
Synonyms β-APP40
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Liquid in 20mM HEPES, pH 7.0, Glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

β-amyloid (Aβ) peptides result from the proteolytic cleavage of β-amyloid precursor protein (APP) which is encoded by a gene located on chromosome 21. Aβ is produced by two proteases (β- and γ- secretase) and has vary forms (39- and 43-mer peptides). Aβ40 and Aβ42 peptides are major constituents of the plaques and tangles that occur in Alzheimer’s disease(AD). Aβ42 plays a critical role in the pathogenesis of AD since its aggregative ability and neurotoxicity are much greater than these of Aβ40. Aβ42 oligomers initially formed as a seed accelerate the aggregation of Aβ40 to form the amyloid plaques that eventually lead to the neurodegeneration (amyloid cascade hypothesis). Aβ40 also serves as an antioxidant molecule by quenching metal ions and inhibiting metal-mediated oxygen radical generation.

Product References

1) Kazuhiro Irie et al. (2005) Journal of bioscience and bioengineering 99(5):437-447. (General)
2) Andreas Kern et al. (2005) Journal of Biological Chemistry. (General)
3) John hardy et al. (2002) Science 297(19):353-356. 4. Zou K. et al. (2003) J Neurochem. 87(3):609-619. (General)

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