Neurosin GST (human) (rec.)
|Synonyms||KLK6; SP59; Zyme; PRSS18; Neurosin; Protease M; EC=3.4.21.-; Kallikrein-6; Serine Protease 9; Serine Protease 18|
Activity has not been tested.
|Formulation||Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by AbFrontier|
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-80°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Product Specification Sheet|
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Neurosin (KLK6), one of these, is a trypsin-like protease dominantly expressed in the human brain but also in a variety of other tissues. As measured by a sensitive quantitative assay in serum and cerebrospinal fluid (CSF), it may have value as a biomarker for diagnosis and monitoring of Alzheimer’s disease (AD). It seems to be down regulated in serum and tissues of AD patients and may be involved in amyloid metabolism.
1) Akira O, et. al. Neurochemistry (2001) vol.12(7) pp.1345 -50. (General)
2) George M, et. al. Clinica Chimica Acta (2003) vol.329, pp.1-8. (General)
3) Georgios P, et. al. BBRC (2004) vol.320 pp.54-61. (General)