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Tumor Necrosis Factor α (human) (rec.)
446
CHF
CHF 446.00
In stock
YIF-LF-P007920 µgCHF 446.00
YIF-LF-P0079A100 µgCHF 1'782.00
| Product Details | |
|---|---|
| Synonyms | Tumor Necrosis Factor Ligand Superfamily Member 2; Cachetin |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human TNF-alpha (aa77-233). |
| Crossreactivity | Human |
| Biological Activity | The ED50 as determined by the cytolysis of murine L929cells in the presense of actinomycin D is 0.03-0.06ng/ml |
| MW | 17.5kDa |
| Purity | ≥98% (SDS-PAGE) |
| Endotoxin Content | <0.05EU/µg purified protein (LAL test; Lonza). |
| Accession Number | P01375 |
| Formulation | Liquid. In 20mM Tris, pH 8.0, 1mM EDTA, 10% Glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | After reconstitution, store at -80°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Tumor necrosis factor-a (TNF-a) is a pleiotropic pro-inflammatory cytokine produced mainly by activated macrophages and in smaller amounts by several other types of cell. TNF-a has been isolated and characterized from a large number of mammals and fish species. TNF-a is expressed in two different forms: a soluble. Mature 17kDa form and a transmembrane 26kDa form. TNF-a interacts with two distinct cell-surface receptors : Tumor necrosis factor receptor 1(TNFR1) and TNFR2. these mediate the cellular actions. The actions of TNF-a are diverse and profound involving inflammation, apoptosis, cell proliferation and the stimulation of various aspects within the immune system. TNF-a is increasingly recognized as a key regulator of lipid metabolism in adipose tissue and protein catabolism in muscle and in disease states such as cancer, Acquired Immune Deficiency Syndrome (AIDS) and obesity-related insulin resistance.
Product References
1) Wen-Xing Ding et al (2004) J.Cell. Mol. Med 8(4);445-454. 2) Sudhir Gupta (2002) Journal of Clinical Immunology 22(4);185-194. 3) Frederick W. goetz et al (2004) Developmental and comparative Immunology 28;487-497. 4) Havell, E.A. (1987) J. Immunol. 39:4225-4231.
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