IL-6 (human) (rec.)
|Synonyms||CDF; IL6; IL-6; BSF-2; IFNB2; IFN-β-2; Interleukin-6; Interferon β-2; Hybridoma Growth Factor; CTL Differentiation Factor; B-Cell Stimulatory Factor 2|
The ED50 of IL-6 is typically 0.3-1 ng/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, B9.
|Formulation||Liquid in PBS, 10% glycerol.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by AbFrontier|
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-80°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Product Specification Sheet|
Interleukin-6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. Human IL-6 molecular weight ranges between 21 and 28 kDa, depending on the state of glycosylation and phosphorylation. Mature human IL-6 is 183 amino acids and shares the homology between human and rat IL-6 is 41% at the amino acid level. IL-6 interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. Two major signalling pathways are activated by IL-6: the JAK/STAT pathway and MAPK cascade.
1) Hoene M and Weigert C., (2008) Obes Rev (1):20-9. (General)
2) Hond DS et al., (2007) Cancer 110(9):1911-28. (General)
3) Knupfer H and Preiss R., (2008) Immunology and Cell Biology 86, 87-91. (General)