IL-6 (human) (rec.)
| Product Details | |
|---|---|
| Synonyms | CDF; IL6; IL-6; BSF-2; IFNB2; IFN-β-2; Interleukin-6; Interferon β-2; Hybridoma Growth Factor; CTL Differentiation Factor; B-Cell Stimulatory Factor 2 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Crossreactivity | Human |
| Biological Activity |
The ED50 of IL-6 is typically 0.3-1 ng/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, B9. |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | 1 mg/ml |
| Formulation | Liquid in PBS, 10% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Interleukin-6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. Human IL-6 molecular weight ranges between 21 and 28 kDa, depending on the state of glycosylation and phosphorylation. Mature human IL-6 is 183 amino acids and shares the homology between human and rat IL-6 is 41% at the amino acid level. IL-6 interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. Two major signalling pathways are activated by IL-6: the JAK/STAT pathway and MAPK cascade.
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