IL-6 (human) (rec.)

CHF 318.00
In stock
YIF-LF-P022120 µgCHF 318.00
 
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Product Details
Synonyms CDF; IL6; IL-6; BSF-2; IFNB2; IFN-β-2; Interleukin-6; Interferon β-2; Hybridoma Growth Factor; CTL Differentiation Factor; B-Cell Stimulatory Factor 2
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Biological Activity The ED50 of IL-6 is typically 0.3-1 ng/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, B9.
Purity ≥95% (SDS-PAGE)
Concentration 1 mg/ml
Formulation Liquid in PBS, 10% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Interleukin-6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. Human IL-6 molecular weight ranges between 21 and 28 kDa, depending on the state of glycosylation and phosphorylation. Mature human IL-6 is 183 amino acids and shares the homology between human and rat IL-6 is 41% at the amino acid level. IL-6 interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. Two major signalling pathways are activated by IL-6: the JAK/STAT pathway and MAPK cascade.
Product References
1) Hoene M and Weigert C., (2008) Obes Rev (1):20-9. (General)
2) Hond DS et al., (2007) Cancer 110(9):1911-28. (General)
3) Knupfer H and Preiss R., (2008) Immunology and Cell Biology 86, 87-91. (General)
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