G-CSF (human) (rec.)

CHF 318.00
In stock
YIF-LF-P027010 µgCHF 318.00
More Information
Product Details
Synonyms CSF3; G-CSF; C17orf33; Filgrastim; Lenograstim; Pluripoietin; Granulocyte Colony-stimulating Factor
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Biological Activity

The ED50 of G-CSF is typically 5-40 pg/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, NFS-60.

Purity ≥95% (SDS-PAGE)
Concentration 0.5 mg/ml
Formulation Liquid in PBS, 10% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that promotes the proliferation and differentiation of cells in the granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-α and IFN-γ. Other cells can also secrete G-CSF after IL-1β,TNF-α and LPS activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF has a effect in the treatment of leukopenia, AIDS, MDS and bone marrow transplantation. In humans, two distinct cDNA clones for G-CSF, encoding 207 and 204 amino acid precursor proteins, have been isolated. Both protein have identical amino acid sequences except for a three amino acid insertion (deletion) at the 35th amino acid residue from the N-terminus of the mature protein.

Product References

1) Fallah MJ et al., (2003) IJMS 28(3):131-134. (General)
2) Panopoulos AD and Watowich SS, (2008) Cytokine 42:277-288. (General)
3) Hirbe AC et al., (2007) Blood 109(8):3424-3431. (General)

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