G-CSF (human) (rec.)

CHF 311.00
In stock
YIF-LF-P027010 µgCHF 311.00
YIF-LF-P0270A100 µgCHF 2'486.00
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Product Details
Synonyms Granulocyte Colony-stimulating Factor; Pluripoietin
Product Type Protein
Source/Host E. coli
Sequence Human G-CSF (aa30-207).
Crossreactivity Human
Biological Activity The ED50 of G-CSF is typically 10-40pg/ml. measured in a cell proliferation assay using a murine myeloblastic M-NFS-60 cell line
MW 19.2 kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <1EU/µg purified protein (LAL test; Lonza).
Concentration 0.5mg/ml
Accession Number P09919
Formulation Liquid. In PBS, 10% glycerol.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Granulocyte colony-stimulating factor(G-CSF) is a hematopoietic cytokine that promotes the proliferation and differentiation of cells in the granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cells can also secrete G-CSF after IL-1b,TNF-alpha and LPS activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF has a effect in the treatment of leukopenia, AIDS, MDS and bone marrow transplantation. In humans, two distinct cDNA clones for G-CSF, encoding 207 and 204 amino acid precursor proteins, have been isolated. Both protein have identical amino acid sequences except for a three amino acid insertion (deletion) at the 35th amino acid residue from the N-terminus of the mature protein.

Product References

1) Fallah MJ et al., 2003, IJMS 28(3):131-134. 2) Panopoulos AD and Watowich SS, 2008, Cytokine 42:277-288. 3) Hirbe AC et al., 2007, Blood 109(8):3424-3431.

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