G-CSF (human) (rec.)

CHF 318.00
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Product Details
Synonyms Granulocyte Colony-stimulating Factor; Pluripoietin
Product Type Protein
Properties
Source/Host E. coli
Sequence Human G-CSF (aa30-207).
Crossreactivity Human
Biological Activity The ED50 of G-CSF is typically 10-40pg/ml. measured in a cell proliferation assay using a murine myeloblastic M-NFS-60 cell line
MW 19.2 kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <1EU/µg purified protein (LAL test; Lonza).
Concentration 0.5mg/ml
Accession Number P09919
Formulation Liquid. In PBS, 10% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Granulocyte colony-stimulating factor(G-CSF) is a hematopoietic cytokine that promotes the proliferation and differentiation of cells in the granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cells can also secrete G-CSF after IL-1b,TNF-alpha and LPS activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF has a effect in the treatment of leukopenia, AIDS, MDS and bone marrow transplantation. In humans, two distinct cDNA clones for G-CSF, encoding 207 and 204 amino acid precursor proteins, have been isolated. Both protein have identical amino acid sequences except for a three amino acid insertion (deletion) at the 35th amino acid residue from the N-terminus of the mature protein.
Product References
1) Fallah MJ et al., 2003, IJMS 28(3):131-134. 2) Panopoulos AD and Watowich SS, 2008, Cytokine 42:277-288. 3) Hirbe AC et al., 2007, Blood 109(8):3424-3431.
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