GM-CSF (human) (rec.)

CHF 318.00
In stock
YIF-LF-P027810 µgCHF 318.00
YIF-LF-P0278A100 µgCHF 2'540.00
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Product Details
Synonyms Granulocyte-macrophage Colony-stimulating Factor; CSF; Colony-stimulating Factor
Product Type Protein
Properties
Source/Host E. coli
Sequence Human GM-CSF (aa18-144).
Crossreactivity Human
Biological Activity The ED50 for this effect is typically 10-40pg/mL. Measured in a cell proliferation assay using the human growth factor-dependent cell line, TF-1.
MW 14.6 kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <1EU/µg purified protein (LAL test; Lonza).
Concentration 0.5mg/ml
Accession Number P04141
Formulation Liquid. In PBS, 10% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Human GM-CSF is a 24 kDa glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising a and b subunits.

Product References

1) Conti L and Gessani S., 2008, Immunobiology 213:859-870. 2) Waller EK., 2007, Oncologist 12:22-6.

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