GM-CSF (human) (rec.)
|Synonyms||Granulocyte-macrophage Colony-stimulating Factor; CSF; Colony-stimulating Factor|
|Sequence||Human GM-CSF (aa18-144).|
|Biological Activity||The ED50 for this effect is typically 10-40pg/mL. Measured in a cell proliferation assay using the human growth factor-dependent cell line, TF-1.|
|Endotoxin Content||<1EU/µg purified protein (LAL test; Lonza).|
|Formulation||Liquid. In PBS, 10% glycerol.|
|Other Product Data||
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|Declaration||Manufactured by AbFrontier.|
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-80°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Product Specification Sheet|
Human GM-CSF is a 24 kDa glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising a and b subunits.
1) Conti L and Gessani S., 2008, Immunobiology 213:859-870. 2) Waller EK., 2007, Oncologist 12:22-6.