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GM-CSF (human) (rec.)
Product Details | |
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Synonyms | Granulocyte-macrophage Colony-stimulating Factor; CSF; Colony-stimulating Factor |
Product Type | Protein |
Properties | |
Source/Host | E. coli |
Sequence | Human GM-CSF (aa18-144). |
Crossreactivity | Human |
Biological Activity | The ED50 for this effect is typically 10-40pg/mL. Measured in a cell proliferation assay using the human growth factor-dependent cell line, TF-1. |
MW | 14.6 kDa |
Purity | ≥95% (SDS-PAGE) |
Endotoxin Content | <1EU/µg purified protein (LAL test; Lonza). |
Concentration | 0.5mg/ml |
Accession Number | P04141 |
Formulation | Liquid. In PBS, 10% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier. |
Shipping and Handling | |
Shipping | DRY ICE |
Short Term Storage | -20°C |
Long Term Storage | -80°C |
Handling Advice | Avoid freeze/thaw cycles. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Human GM-CSF is a 24 kDa glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising a and b subunits.
1) Conti L and Gessani S., 2008, Immunobiology 213:859-870. 2) Waller EK., 2007, Oncologist 12:22-6.