α-Synuclein (human) (rec.)

CHF 366.00
In stock
YIF-LF-P03100.2 mgCHF 366.00
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Product Details
Synonyms SNCA; NACP; α-Synuclein; Non-A β Component of AD Amyloid; Non-A4 Component of Amyloid Precursor
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM Tris, pH8.0, 10mM NaCl, 130mM imidazole.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein. α-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19 kDa that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson's disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation.α-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this α-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of α-Synuclein are associated with autosomal dominant Parkinson's disease. The mutations increase the aggregation rate of the resultant α-synuclein.

Product References

1) Wakabayashi K et al. (2007) Neuropathology 27(5):494-506. (General)
2) Beyer K., (2006) Acta Neuropathol 112(3):237-251. (General)
3) Bruening W et al., (2000) Cancer 88(9):2154-2163. (General)

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