Moesin (human) (rec.)
| Product Details | |
|---|---|
| Synonyms | MSN; Moesin; Membrane-organizing Extension Spike Protein |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Crossreactivity | Human |
| Purity | ≥95% (SDS-PAGE) |
| Formulation | Lyophilized from 20mM HEPES, pH7.0. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | After reconstitution, store at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. The ERM proteins have a crucial role in organizing membrane domains through their ability to interact with transmembrane proteins and the cytoskeleton. The C-terminal domain may form an intramolecular band to the N-terminal four-point-one ERM homology domain or may bind to F-actin depending on the phosphorylation state of a conserved threonine residue (Thr567 in ezrin, Thr564 in radixin, and Thr558 in moesin). An essential role of the 78-kDa protein Moesin is described for Rho- and Rac-dependent assembly of actin filaments.
1) Rudiger Blindta et al., (2002) Cardiovascular Research 54:630–639. (General)
2) Xiaohua Guo et al.,Am J Physiol Heart Circ Physiol|(2009) 297: H238–H246. (General)
