DJ-1 (human) (rec.)

CHF 366.00
In stock
YIF-LF-P04010.2 mgCHF 366.00
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Product Details
Synonyms PARK7; Oncogene DJ1; Protein DJ-1; Parkinson Disease Protein 7
Product Type Protein
Properties
Source/Host E. coli
Crossreactivity Human
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from 20mM Tris, pH8.0 / 10mM NaCl.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability After reconstitution, store at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease, with a prevalence of 1–2% in population aged 65 years or older. PD is a complex, multifactorial disorder that typically manifests after the age of 50 years. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. α-synuclein and parkin are thought to be firmly associated with PD. The exact biological function of the DJ-1 protein is currently unknown. It may play a role in the oxidative stress response, and this function could be important in preventing the onset of PD. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson disease 7 (PARK7). The human DJ-1 protein contains 189 amino acid residues. DJ-1 may possess an active site and could also be a protease/hydrolase similar to the PfpI proteases. The DJ-1 gene has been highly conserved in evolution. The structures of the mouse and human DJ-1 genes are similar, and human and mouse DJ-1 proteins display 90% amino acid identity.

Product References

1) Bonifati V et al. (2004) J. Mol. Med. 82 (3): 163–174. (General)
2) Tao X and Tong L, (2003) J. Biol. Chem. 278 (33): 31372–31379. (General)
3) Bonifati V et al. (2003) Science. 299:256-259. (General)

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