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anti-Ferredoxin Reductase, pAb
Product Details | |
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Synonyms | AR; ADXR; FDXR; EC=1.18.1.6; Ferredoxin Reductase; Adrenodoxin Reductase; Ferredoxin-NADP(+) Reductase; NADPH:Adrenodoxin Oxidoreductase, Mitochondrial |
Product Type | Polyclonal Antibody |
Properties | |
Immunogen/Antigen | Recombinant human fragment protein purified from E. coli. |
Application |
Western Blot (1:3,000) |
Crossreactivity |
Human Mouse Rat |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Ferredoxin reductase is a ubiquitous flavoenzyme, containing noncovalently bound FAD as a prosthetic group (1). It plays a role in delivering NADPH or low potential one-electron donors such as ferredoxin and flavodoxin to redox-based metabolisms in plastids, mitochondria and bacteria (2). In mammals, ferredoxin reductase is loosely associated with the inner mitochondrial membrane and receives electrons from NADPH. These electrons are transferred to ferredoxin which shuttles electrons to cytochrome P450 in the adrenal cortex mitochondrial steroid hydroxylation systems (3). Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-β hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
1) Carrillo, N. and Ceccarelli, E. D. (2003) Eur. J. Biochem. 270, 1900-1915. (General)
2) Lambeth, J. D. and Kamin, H. (1977) J.Biol. Chem. 252, 2908-2917. (General)
3) Lin, D. et al. (1990) Proc. Natl. Acad. Sci. USA. 87, 8516-8520. (General)