anti-Peroxiredoxin 6-SO3, pAb

CHF 322.00
In stock
YIF-LF-PA0005100 µlCHF 322.00
More Information
Product Details
Synonyms AOP2; NSGPx; PRDX6; aiPLA2; 1-Cys PRX; EC=3.1.1.-; EC=1.11.1.9; EC=1.11.1.15; 24 kDa Protein; Peroxiredoxin-6; 1-Cys Peroxiredoxin; Liver 2D Page Spot 40; Antioxidant Protein 2; Sulfonylated
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Sulfonylated peptide (KLH coupled) corresponding to the active site sequence common to mammalian Prx 6.
Application

Western Blot (1:2,000)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Peroxiredoxin VI (Prx 6, 1-Cys Prx) is a member of Peroxiredoxin Family, an antioxidant enzyme that detoxifies reactive oxygen species and has a cysteine at their active site. Six isoforms (Prx 1 to 6) of Prx exist in all eukaryotic cells. These isoforms are classified into three subgroups (2-Cys, atypical 2-Cys, and 1-Cys). Prx 6 modulates various receptor-signaling pathways and protects cells from cell death induced by oxidative stress. The active site cysteine (Cys47) is oxidized to cysteine sulfenic acid (Cys47-SOH) by H2O2. However, the resulting Cys47-SOH does not form a disulfide bond because of unavailability of another Cys-SH nearby. It can be reduced by nonphysiological thiols such as DDT but is not transformed by Thioredoxin/Thioredoxin Reductase or GSH. Occasionally, the sulfenic intermediate is hyperoxidized to sulfinic or sulfonic acid, resulting in inactivation of peroxidase activity. Involved in redox regulation of the cell. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Product References

1) Chae, H.Z., et al (1994) Proc.Natl. Acad. Sci. USA 91:7017-7021. (General)
2) Choi, H.J. et al (1998) Nat. Struct. Biol 5:400-406. (General)
3) Fisher, A.B., et al (1999) J. Biol. Chem. 274:21326-21334. (General)
4) Kang, S.W. et al (1998) J. Biol. Chem. 273:6303-6311 (General)
(5) Seo, M.S., (2000) J.Biol. Chem. 275:20346-20354. (General)

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