anti-Peroxiredoxin 3, pAb

CHF 322.00
In stock
YIF-LF-PA0030100 µlCHF 322.00
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Product Details
Synonyms AOP1; AOP-1; PRDX3; HBC189; Prx-III; EC=1.11.1.15; Peroxiredoxin-3; Peroxiredoxin III; Protein MER5 Homolog; Antioxidant Protein 1; Thioredoxin-dependent Peroxide Reductase, Mitochondrial
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human fragment protein (without mitochondrial leader sequence) purified from E. coli.
Application

Western Blot (1:2,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1). Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-κ-B in the cytosol.

Product References

1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)

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