anti-Caspase-2, pAb

CHF 322.00
In stock
YIF-LF-PA0044100 µlCHF 322.00
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Product Details
Synonyms ICH1; CASP2; EC=3.4.22.55
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

ELISA
Western Blot (1:100)
IHC-P (1:200)

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Caspase-2 is an enzyme involved in the programmed cell death process and one of the best-conserved caspases across species. Caspase-2 is unique among caspases in that it has features of both initiator and effector caspases. Two different mRNA species, derived from alternative splicing, encode two proteins, caspase-2L (435 amino acids) and caspase-2S (312 amino acids), which have antagonistic effects on cell death although it is not clear that the shorter form is expressed as a protein. Caspase-2 appears to be necessary for the onset of apoptosis triggered by several insults, including DNA damage, administration of TNF, and different pathogens and viruses. Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Product References

1) Zhivotovsky B, et al, (2005) Biochem Biophys Res Commun. vol.331(3): pp.859-67. (General)
2) Troy CM, et al, (2003) Cell Death Differ. vol.10(1): pp.101-7. (General)

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