anti-JNK1, pAb

CHF 322.00
In stock
YIF-LF-PA0047100 µlCHF 322.00
More Information
Product Details
Synonyms JNK1; MAPK8; SAPK1c; MAPK 8; JNK-46; EC=2.7.11.24; MAP Kinase 8; c-Jun N-terminal Kinase 1; Stress-activated Protein Kinase 1c; Mitogen-activated Protein Kinase 8; Stress-activated Protein Kinase JNK1
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:1,000~2,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson's and Alzheimer's diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain. Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: β-1 preferentially binds to c-Jun, whereas α-1, α-2, and β-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Product References

1) Waetzig V. et al, (2005) Trends Pharmacol Sci. vol.26(9): pp.455-61. (General)
2) Gelderblom M. et al, (2004) Int J Dev Neurosci. vol.22(7): pp.559-64. (General)
3) Bogoyevitch MA. et al. (2004) Biochim Biophys Acta. vol.1697(1-2): pp.89-101. (General)

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